Shellfish poisons chemistry

The use of high performance liquid chromatography (HPLC) for the study of paralytic shellfish poisoning (PSP) has facilitated a greater understanding of the biochemistry and chemistry of the toxins involved. HPLC enables the determination of the type and quantity of the PSP toxins present in biological samples. An overview of the HPLC method is presented that outlines the conditions for both separation and detection of the PSP toxins. Examples of the use of the HPLC method in toxin research are reviewed, including its use in the determination of the enzymatic conversion of the toxins and studies on the movement of the toxins up the marine food chain. 

In the past several years we have witnessed tremendous development in the chemistry and biology of paralytic shellfish poisons (PSP). 

Shimizu, Y. "Paralytic Shellfish Poisons" In "Progress in the Chemistry of Organic Natural Products" Herz, W. Griesbach, H. Kirby, G. W., Eds. Springer-Verlag Wien-New York, 1983,... 

Shimizu, Y, Paralytic shellfish poisons, in Progress in the Chemistry of Organic Natural Products, Herz, W., et al., eds.. Springer-Verlag, New York, p. 235, 1984. 

Contents D. A. H. TAYLOR The Chemistry of the Limonoids from Melia-ceae. — J. A. ELIX, A. A. WHITTON, M. V. SARGENT Recent Progress in the Chemistry of Lichen Substances. — Y. SHIMIZU Paralytic Shellfish Poisons. 

P. Vale, Chemistry of diarrhetic shellfish poisoning toxins, in L.M. Botana (Ed.), Phytotoxins, Chemistry and Biochemistry, Blackwell Publishing, Ames, Iowa, 2007, pp. 211-223. 

Twiner, M.J., Rehmarm, N., Hess, P., and Doucette, G.J. (2008) Azaspiradd shellfish poisoning A review on the chemistry, ecology, and toxicology with an emphasis on human health impacts. Mar. Drugs, 6, 39-72. 

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