Shape design algorithm

The design of more complex cross-section geometries has either been based on the Universal Method (UM) of braiding or on the shape design algorithm (SDA). The UM is based on using multiple distinct four-step braid cycles per machine cycle, whereas the SDA leads to one complex braiding pattern per machine cycle (Pastore, 1988 Kostar, 1998). 

For the reasons outlined above, our efforts concentrated on the design and experimental verification of short RNA sequences which can adopt two different secondary structures. Implicit was the principal question what is the minimum size of an RNA that is still able to appear in different defined shapes In this context, the closest study we found was a theoretical approach by C. Flamm et al. [28], who developed an algorithm to design multistable RNAs [29]. To the best of our knowledge, however, there is no experimental data verifying the multistable sequence examples suggested therein. 

---