SH2 Domains as Drug Targets

Despite these difficulties, significant progress has been made in discovering pharmaceuticals which target particular SH2 domains. For instance, a difficulty originally associated with tyrosine phosphorylated 

The SH2 domain of Crb2 is perhaps the most selective SH2 domain in terms of target recognition there is a strict requirement for Asn 2 residues C-terminal to the pTyr (McNemar et al., 1997 Songyang et al.. 

Cousins-Wasti, R., Ingraham, R. H., Morelock, M. M., and Grygon, C. A. (199G). Biochemistry 

Sicheri, E, and Kuriyan, J. (1997). Curr. Opin. Struct. Biol. 7, 777-785. 

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy 

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