Sex hormones and drugs

In (he ttvary. FSH (and LH) stimulates follicular development (middle left. A-B) and estradiol synthesis by the granulosa cells of ilie follicle. In the early follicular phase, the low esiradio level in the blood (middle leR) exerts a negative feedback effeei on FSH, ensuring that 

GnKH (gonadorelin) is a decapeptidc that. stimulates FSM and LM relea.se from the anterior pituitaiy gland. Pulsatile infusions of GnRH arc used to treat hypothalamic hypogonadism. 

Lit and PSH are glycoprotein hormones produced by the anterior pituitary. They regulate gonadal function. 

In iuiovulaiory women, tiifertiliiy may be overcome provided that the ovary is capable of producing mature ova and the appropriate steroids. 

Tlie tnosi important andcogen in liuman.s is testosterone. About 2% of icsiosicrone in the plasma is free and in the skin, prostate, seminal ve.sicles and epididymis it i.s converted to diliydrotes(osterone. Androgen deficiency is usually treated with intramuscular depot injections of 

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