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Seven-membered rings aldol reaction cascade

Michael addition, followed by an intramolecular aldol condensation to provide the seven-membered ring. Subsequent retro-Dieckmann reaction, dehydration, and ester saponification provide the bicyclic product in 98% yield. A related cascade reaction was recently reported by the same research group in which the reactions of various allylic halides with cyclopentanone derivatives provide seven-membered rings. ... [Pg.7]


See also in sourсe #XX -- [ Pg.623 ]

See also in sourсe #XX -- [ Pg.623 ]

See also in sourсe #XX -- [ Pg.623 ]




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