Serum anticholinergic activity

McShane R, Keene J, Gedling K et al. (1997) Do neuroleptic drugs hasten cognitive decline in dementia Prospective study with necropsy follow up. BMJ 314(7076) 266-270 Mortimer AM, Shepherd CJ, Rymer M et al. (2005) Primary care use of antipsychotic drugs an audit and intervention study. Ann Gen Psychiatry 4 18 DOI 10.1186/1744-859X-4-18 Mulsant BH, Pollock BG, Kirshner M et al. (2003) Serum anticholinergic activity in a community-based sample of older adults relationship with cognitive performance. Arch Gen Psychiatry 60(2) 198-203... 

Carnahan RM, Lund BC, Perry PJ, Pollock BG, Culp KR. The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden associations with serum anticholinergic activity. J Clin Pharmacol 2006 46(12) 1481-6. 

Hori K, Konishi K, Watanabe K, Uchida H, Tsuboi T, Moriyasu M, Tominaga I, Hachisu M. Influence of anticholinergic activity in serum on clinical s5miptoms of Alzheimer s disease. Neuro-psychobiology 2011 63(3) 147-53. 

Carbinoxamine compound syrup (Pennex) containing 60 mg pseudoephedrine HCl, 4 mg carbinoxamine maleate, and 15 mg dextromethorphan HBr in 0.2% alcohol is indicated for relief of cough and upper respiratory systems including nasal congestion associated usually with allergy or common cold. Carbinoxamine possesses Hj antihistaminic activity with mild anticholinergic-sedative properties. Carbinoxamine, which is metabolized completely, has a serum half-life of 10 to 12 hours. 

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