Sertindole Protease inhibitors

ARIPIPRAZOLE, HALOPERIDOL, CLOZAPINE, PIMOZIDE, RISPERIDONE, SERTINDOLE PROTEASE INHIBITORS Possibly T levels of antipsychotic Inhibition of CYP3A4- and/or CYP2D6-mediated metabolism Avoid co-administration of clozapine with ritonavir, and pimozide or sertindole with protease inhibitors. Use other antipsychotics with caution as 1 dose may be required with risperidone, watch closely for extrapyramidal side-effects and neuroepileptic malignant syndrome... 

The protease inhibitor are all, to varying degrees, inhibitors of the cytochrome P450 isoenzyme CYP3A4 by which sertindole is metabolised. The manufacturers therefore contraindicate concurrent use, as raised sertindole levels may lead to torsade de pointes arrhythmias, which are potentially life-threatening. ... 

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