Serotonin receptors cerebellum

Monoamines Ginseng has complex effects on endogenous monoamines. After two weeks of treatment, turnover of dopamine and norepinephrine is increased in the cerebral cortex, and serotonin turnover is increased in the striatum and cerebellum (Itoh et al. 1989). However, dopamine turnover in the striatum is reduced, as is serotonin in the hypothalamus and midbrain. After seven weeks of treatment, on the other hand, serotonin turnover in the cerebellum is increased, but turnover of dopamine, norepinephrine, and serotonin is reduced in all other areas studied. Ginsenosides Rbl and Rgl decrease 5-HT levels or reduce 5-HT turnover (Zhang et al. 1991). There is no specific binding observed of Rgl and Rbl adrenergic (ol o2, or j8), dopamine, or 5-HT receptors. 

Maura G, Raiteri M. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. J Neurochem 1996 66 203-209. 

Marcoli M, Maura G, Tortarolo M, Raiteri M. Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in rat cerebellum involvement of 5-hydroxytryptamine2C receptors. J Neurochem 1997 69 427-430. 

Eastwood SL, Burnet PWJ, Gittins R, Baker K, Harrison PJ. Expression of serotonin 5-HT2A receptors in the human cerebellum and alterations in schizophrenia. Synapse 2001 42 104-114. 

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