Serious Hazards of Transfusion

Management of adverse drug reactions Preferential use of male donor plasma for FFP transfusions has led to a substantial reduction in the incidence of TRALI [6, 12 ]. Serious Hazards of Transfusion (SHOT) data suggest a 50% reduction in the risk of TRALI when 99% of FFP is from male donors only [33 ]. In another study, 12 of 21 allo-immune TRALI cases implicated plasma from female donors, suggesting that theoretically 57% of all allo-immune TRALI cases could be prevented by using male plasma only [14 ]. In another study there was no statistically significant difference in pulmonary morbidity between patients who received units from female or male donors, but these results were limited by the small number of morbid outcomes [11 ]. 

SHOT. Serious Hazards of Transfusion. Annual Report 2009. http //www.shotuk. org/wp-content/uploads/2010/07/SHOT20 09.pdf. 

Stainsby D, Jones H, Wells AW, Gibson B, Cohen H. Adverse outcomes of blood transfusion in children analysis of UK reports to the serious hazards of transfusion scheme 1996-2005. Br J Haematol 2008 141(1) 73-9. 

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