Serine-palmitoyl-transferase

Despite the fact that cestodes appear to be capable of considerable lipid synthesis, the actual pathways and enzyme systems involved have been little studied. Sphingomyelin synthesis has been investigated in H. diminuta (37), where it probably involves the same five-step pathway thought to occur in vertebrates involving the enzymes serine palmitoyl-transferase,... 

L-cycloserine is an inhibitor of serine palmitoyl transferase (85), the first committed step in GSL biosynthesis. However, because this inhibitor prevents the synthesis of the highly bioactive ceramide, an interpretation of GSL depletion is equivocal. 

Antifungal aminopolyhydroxy fatty acids from cultures of Aspergillus fumigatus and Paecilomyces variotii. S. inhibit serine palmitoyl transferase (EC 2.3.1.50), e. g., S. B C20H39NO6, Mr 389.53, cream-colored solid. A S. derivative has been in preclinical development as an antimycotic agent. 

Weiss B, Stoffel W. Human and murine serine-palmitoyl-CoA transferase-cloning, expression and characterization of the key 26. enzyme in sphingolipid synthesis. Eur. J. Biochem. 1997 249 239-247. 

Hojjati MR, Li Z, Jiang XC. Serine palmitoyl-CoA transferase (SPT) deficiency and sphin-golipid levels in mice. Biochim Biophys Acta 1737(2005a) 44-51. 

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