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Serine hydrolase-catalyzed ester hydrolysis modelling

Pig Liver Esterase (PLE). This is the more used car-boxylesterase (carboxylic-ester hydrolase, EC 3.1.1.1, CAS 9016-18-6) which physiologically catalyzes the hydrolysis of carboxylic acid esters to the free acid anion and alcohol. PLE is a serine hydrolase which has been widely used for the preparation of chiral synthons and these applications have been fully reviewed. An active-site model for interpreting and predicting the specificity of the enzyme has been published. In the pioneering studies of the enzyme applications field, PLE was used for the chiral synthesis of mevalonolactone. Prochiral 3-substituted glutaric acid diesters... [Pg.330]

See other pages where Serine hydrolase-catalyzed ester hydrolysis modelling is mentioned: [Pg.586]    [Pg.131]    [Pg.547]    [Pg.398]    [Pg.171]   
See also in sourсe #XX -- [ Pg.14 , Pg.81 ]

See also in sourсe #XX -- [ Pg.14 , Pg.81 ]

See also in sourсe #XX -- [ Pg.14 , Pg.81 ]

See also in sourсe #XX -- [ Pg.14 , Pg.81 ]



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Ester hydrolases

HYDROLYSIS MODEL

Hydrolases catalyzed

Hydrolases serine hydrolase

Serine esters

Serine hydrolase

Serine hydrolase-catalyzed ester hydrolysis

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