Sequestration-enabling reagents

Direct sequestration of a reactant by an insoluble resin is impractical if the kinetics is sluggish and impossible if the solution-phase reactant does not contain a functionality to enable direct sequestration. These limitations led several research groups to use bifunctional solution-phase linking reagents, also referred to as sequestration-enabling-reagents. 33... 

Parlow, J. J. Naing, W. South, M. S. Flynn, D. L. In Situ Chemical Tagging Tetrafluorophthalic Anhydride as a Sequestration Enabling Reagent (SER) in the Purification of Solution-Phase Combinatorial Libraries, Tetrahedron Lett. 1997, 38, 7959. 

Parlow JJ, Naing W, South MS, Flynn DL, In situ chemical tagging tetrafluorophthalic anhydride as a sequestration enabling reagent (SER) in the purification of solution-phase combinatorial libraries, Tetrahedron Lett., 38 7959-7962, 1997. 

Figure 8.35 Solid-supported scavengers sequestration-enabling reagents 8.65-8.70.

A. Dondoni, A. Marra, and A. Massi, Hybrid solution/solid-phase synthesis of oligosaccharides by using trichloroacetyl isocyanate as sequestration-enabling reagent of sugar alcohols, Angew. Chem. Int. Ed., 44 (2005) 1672-1676. 

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