Sequential Organ Failure Assessment

Observational studies Adverse reactions to amphotericin B deoxycholate have been studied in a retrospective analysis of 39 courses of treatments in 33 Chilean patients 1% On average, therapy lasted 12 (range 2-39) days and the cumulative dose was 600 (100-1950) mg. In 63% of cases 24-hour infusions were used and 36% received a 4-to 6-hour infusion. In addition, 37% received daily an infusion of saline before amphotericin. There were adverse reactions in 40% of treatments fever was the most common (25%). Nephrotoxicity was relatively infrequent (9.4%), and it affected only patients without previous renal disease and not requiring dialysis. Hypokalemia developed in 22% of treatments. In a multivariate analysis, age over 60 years was an independent factor for infusion-related adverse reactions and a Sequential Organ Failure Assessment (SOFA) score over 3 and glucocorticoid administration at the same time as amphotericin were independently associated with fatal outcomes. 

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