Sequence-specific polymer

Identity Sequence-specific polymers of amino acids Sequence-specific polymers of N-substituted glycines... 

Keywords High-precision polymer Secondary structure Self-assembly Sequence-specific polymer Synthetic biology Tertiary structure... 

Recently, Teymour and coworkers developed an interesting computational technique called the digital encoding for copolymerization compositional modeling [20,21], Their method uses symbolic binary arithmetic to represent the architecture of a copolymer chain. Here, each binary number describes the exact monomer sequence on a specific polymer chain, and its decimal equivalent is a unique identifier for this chain. Teymour et al. claim that the... 

Protein polymers based on Lys-25 were prepared by recombinant DNA (rDNA) technology and bacterial protein expression. The main advantage of this approach is the ability to directly produce high molecular weight polypeptides of exact amino acid sequence with high fidelity as required for this investigation. In contrast to conventional polymer synthesis, protein biosynthesis proceeds with near-absolute control of macromolecular architecture, i.e., size, composition, sequence, topology, and stereochemistry. Biosynthetic polyfa-amino acids) can be considered as model uniform polymers and may possess unique structures and, hence, materials properties, as a consequence of their sequence specificity [11]. Protein biosynthesis affords an opportunity to completely specify the primary structure of the polypeptide repeat and analyze the effect of sequence and structural uniformity on the properties of the protein network. 

The idea of conformation-dependent sequence design via polymer-analogous transformation can be generalized in many respects [23]. Indeed, a special chemical sequence can be obtained not only from a globular conformation any specific polymer chain conformation can play the role of parent. 

The ability to tailor functional polymeric structures is highly dependent on the level of control in their synthesis. Although tremendous progress has been made in the chemical synthesis of polymers, the degree of control and diversity of monomers afforded by protein polymers remains unsurpassed (1). Natural proteins possess precise molecular weights and high sequence specificity that... 

The sequence length can be found from a series of physical and chemical methods. Generally, all the methods are strongly dependent on the polymer constitution thus they can often only be applied to a specific polymer. 

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