Sequence in peptides

B.2.6 Determination of Amino Acid Composition and Sequence in Peptides.200... 

One additional important concept to consider is that of peptide classification. If each sequence in peptide space is considered an individual species, then our clusters of green boxes are representative of a higher order of classification, the genus. With this concept in mind, Table 1 is an attempt to produce a generic classification of peptides. The number of individual species in each genus is, of course, variable and no doubt the future will see the evolution of new genera... 

P. Edman, Method for determination of the amino add sequence in peptides, Acta Chem.Scand. 4 283 (1950). 

Fractional factorial designs in principal properties have also been used to design aminoacid sequences in peptides in studies on quantitative structure activity relations. [10]... 

As of this writing, 50 years have passed since Pehr Edman published his first note on chemical degradation of peptide chains, A Method for the Determination of the Amino Acid Sequence in Peptides. As testament to the continuing relevance of this technique, the following job announcement was recently posted. 

Edman, R, A method for the determination of the amino acid sequence in peptides. Arch. Biochem., 22, 475 76, 1949. 

By definition, a structural subunit is repeated periodically in an oligomer or in a polymer inducing a corresponding periodicity of fragmentation in the mass spectrometer. If a fragmentation series due to such a periodicity of structure is detectable, an analysis of the sequence of monomers in oligomers is possible. This may be discussed in the case of amino acid sequencing in peptides ... 

K. Biemann, F. Gapp, J. Seibl, Application of mass spectrometry to stracture problems I, Amino acid sequence in peptides. J. Amer. Chem. Soc. 81 2274-2275 (1959)... 

P. Edman, Determination of the amino acid sequence in peptides. Arch. Biochem. 22 475-476 (1949) also Method for the determination of the amino acid sequence in peptides. Acta Chem. Scand. 4 283-293 (1950) Stepwise degradation of peptides via phenylthiohydantoins. Acta Chem. Scand. 7 700-701 (1953)... 

Used (with octadecanoic acid) for amino acid sequencing in peptides. Cryst. (pet. ether). Mp 62-63°. 

Constit. of most vegetable and animal fats. Acid and derivatives widely used as additives to industrial preparations. Used as EtOH soln. for nephelometric detn. of Ca. Used (with heptadecanoic acid) for amino acid sequencing in peptides. Leaflets. Sol. EtOH, C Hg, CHCI3 si. sol. H2O. Mp 69.7°. Bp5 213°. 

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