Sequence homologies substitution matrices

Biglycan shares substantial sequence homology with decorin, and it has four core protein domains as described above for decorin [29, 33]. However, it differs from decorin in that it is substituted with two dermatan sulfate or chondroitin sulfate chains near its N-terminus. Despite the overall similarity between decorin and biglycan, these two molecules have, in many instances, different tissue distributions. This is especially apparent in human skin where decorin is associated with extracellular matrix and fibrillar collagen bundles, while biglycan is principally found in association with epithelial structures, the epidermis, and vascular endothelial cells [6]. 

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