Sepsis clinical manifestations

The clinical presentation of sepsis varies and the rate of development of clinical manifestations may differ from patient to... 

Balk RA. Severe sepsis and septic shock Definitions, epidemiology, and clinical manifestations. Crit Care Clin 2000 16 179-192. 

Pathological findings frequently observed in organs of patients who have died of sepsis include disseminated intravascular coagulation (DIC), manifested as diffuse thrombotic occlusions in the entire microvascular system, associated with alterations in the hemostatic mechanism and clinical signs of hemorrhagic diathesis. Many observations indicate that DIC contributes to the major symptoms of the systemic inflammatory response syndrome (SIRS), which frequently complicate sepsis (HI, H2, H3, T6). 

The clinical presentation of these 7 cases was that of a spectrum involving the kidneys with GIT manifestations in all, as well as hepatic failure in two. Sepsis and hemorrhage were secondary manifestation of mucosal damage and in one case, rectal perforation (probably traumatic enema) was an additional finding. 

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