Sentinel method experimental design

Figure S.22 Experimental design as used in the Sentinel method of Glajch et al. [542). Figure taken from ref. (565). Reprinted with permission.

Summary of mobile phase compositions to be used in the experimental design for the Sentinel method. 

Summary of mobile phase compositions to be used in the experimental design for the Sentinel-method as applied to LSC. Selectivity parameters for LSC solvents according to the experimental design of figure 5.22. 

The Sentinel method is the outstanding exponent of the group of interpretive methods, as it has already been applied successfully for selectivity optimization in programmed solvent LC. However, other interpretive methods, based either on fixed experimental designs or on iterative procedures, can be applied along the same lines. It was seen in section 6.3.2.3 that the extension of the Sentinel method to incorporate gradient optimization was fairly straightforward. 

---