Sendai virus sialidase

The internal, sialyl residue of GM, is not completely resistant to some sialidases, so long as the oligosaccharide chain is bound to the ceramide part of GM, it is slowly cleaved by C. perfringens sialidase in the presence of bile salts.77 57 3511 Surprisingly, it is a relatively good substrate for the A. ureafaciens sialidase.360 Rapid hydrolysis of GM, sialic acid has also been observed with Sendai virus sialidase, in contrast to the enzymes from NDV or influenza viruses.361 Susceptibility towards mammalian sialidases has also been reported.362 However, it... 

In a recent paper (3l) it was demonstrated that the removal of sialic acid from human erythrocytes with Vibrio oholerae sialidase abolished hemagglutination by Sendai virus. Hemagglutination titers were restored selectively by the incorporation of NeuAc with 8-galactoside a2-+3sialyltransferase which has a strict... 

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