Semioxamazide, 5-

Nifuraldezone. Aminooxoacetic acid [(5-nitro-2-furanyl)methylene]-hydrazide, nifiiraldezone, is prepared by the reaction of 5-nitro-2-furancarboxaldehyde with semioxamazide. The product is useful in the treatment of dysentery in calves (39). 

Semioxamazide.—A gravimetric method for the estimation of cinnamic-aldehyde in cassia and cinnamon oils, but which appears to apply only to this aldehyde, has been devised by Hanus based on the formation of a crystalline semioxamazone when cinnamic aldehyde is treated -with semioxamazide, the reaction being—... 

Reaction CXXXl. Formation of Semioxamazones.—Semioxamazide, NH2.CO.CO.NH.NH2, possesses similar properties to semicarbazide, and reacts well with aldehydes, but with ketones the reaction does not seem to be generally applicable. 

The aldehydes or ketones and the semioxamazide are weighed in molecular proportions, and when the former are insoluble in water it is best to dissolve them in a small quantity of alcohol. The semioxamazide, dissolved in the minimum quantity of water, is then added and the mixture thoroughly shaken for some time, when a precipitate of the semi-... 

Salicylamide, h98 Salicylanilide, hl61 Salicylic acid, h99 Salol, pl50 Sarcosine, m258 Sebacic acid, d9 Sebacoyl chloride, dl 1 Semioxamazide, 053... 

Effect of Pressure on Proton-Coupled Electron Transfer Reactions of Seven-Coordinate Iron Complexes in Aqueous Solution It has been shown that seven-coordinate Fe(III) diaqua complexes consisting of a pentaaza macrocyclic ligand possess superoxide dismutase (SOD) activity, and therefore could serve an imitative SOD function.360 Choosing appropriate chemical composition of a chelate system yielded suitable pKa values for the two coordinated water molecules so that the Fe(III) complexes of 2,6-diacetylpyridine-bis(semicarbazone) (dapsox) and 2,6-diacetylpyridine-bis(semioxamazide) (dapsc) (see Scheme 7.12) would be present principally in the highly active aqua-hydroxo form in solution at physiological pH.361... 

Hepta-coordinate 3d metal complexes are relatively rare and solution reactions of such complexes have not been investigated systematieally. Iron (III) forms a seven-coordinate complex with 2,6-diacetylpyridine-bis-(semioxamazide) (H2dapsox). 

The checkers used Aldrich gold label (R)-( + )-a-phenethylamine and obtained [a]D +110° for the (R) semioxamazide. 

More versatile complexes such as aryl aldehyde complexes have been resolved by the chromatographic separation of diastereoisomeric derivatives such as semioxamazones (5) prepared with (5)-(-)-5-(a-phenylethyl) semioxamazide, imines (6) prepared from L-valinol or aminals (7) prepared from chiral diamines." Separation is, in general, easy and efficient because the complexes involved are highly coloured in addition, the subsequent hydrolysis to release the aldehyde functional group proceeds quantitatively. 

Hanus publishes a new method for the determination of cinnamic aldehyde in cassia and cinnamon oils depending on the comibination of the aldehyde with semioxamazide. Ten grms. of finely powdered hydrazine sulphate are dissolved in a solution of 9 grms. of caustic soda... 

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