Self-Assembly of Lipophilic Guanosine Analogs

More recently, Gottarelli s group described another unique self-assembled structure built from the self-assembly of a lipophilic 8-oxoG derivative 4. This 

As mentioned above, hydrogen-bonded G ribbons can be converted to stacked cyclic G-quartets upon addition of a templating cation. To better understand the organization of these lipophilic G-quartets within higher ordered G-quadruplex structures, our group collaborated with Gottarelli s group to solve the NMR structure of [dG 3]g KI in CDCh. Remarkably, this discrete octamer 

The bound cations in these lipophilic G-quadruplexes have been directly observed using solid-state NMR spectroscopy. Wu and colleagues used Na 

3 Controlling Supramolecular Structure with Monomer Building Blocks 

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