Selectivity enhancement methods high-speed

In another paper, a development of the microwave-assisted parallel solid-phase synthesis of a collection of 21 polymer-bound enones was described. The two-step protocol involves initial high-speed acetoacetylation of polystyrene resins with a selection of seven common P-ketoesters. When microwave irradiation at 170 °C was employed, complete conversions were achieved within 1-10 min, a significant improvement over the conventional thermal method, which takes several hours for completion. Significant rate enhancements were also observed for the subsequent microwave-heated Knoevenagel condensations. Reaction times were reduced to 30-60 min at 125 °C in the microwave protocol compared to 1-2 days using conventional thermal conditions. Kinetic comparative studies indicate that the observed rate enhancements can be attributed to the rapid direct heating of the... 

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