Selective toxicity cisplatin/carboplatin

Phosphonic acids have been used to substitute the dicarboxylate moiety in carboplatin and oxaliplatin in order to improve solubility and pharmacological properties such as mmor selectivity and general toxicity (Fig. 13.6) [23, 24]. The introduction of the phosphonic functionality led to complexes active in smdies on several mmor models with activity found to be similar or better than cisplatin or carboplatin although severe kidney toxicity was observed in vivo [23]. 

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