Selective serotonin reuptake inhibitors extended-release

SSRI, selective serotonin reuptake inhibitor XR, extended-release. 

Venlafaxine extended release, duloxetine, paroxetine, and escitalopram are FDA approved for treatment of GAD. Sertraline is also effective. Acute response and remission rates are approximately 65% and 30%, respectively. Imipramine may be used when patients fail to respond to selective serotonin reuptake inhibitors (SSRIs). In one trial, diazepam, trazodone, and imipramine had greater anxiolytic activity than placebo. 

Note. L=liquid CR=controlled release SR=sustained-release XR=extended-release soltab=orally disintegrating tablets MAOI=monoamine oxidase inhibitor MAO A=monoamine oxidase A SSRI=selective serotonin reuptake inhibitor SNRI=sCTotonin-norepinephrine reuptake inhibitor. 

Oral 25, 37.5, 50, 75, 100 mg tablets 37.5, 75, 150 mg extended-release tablets Selective Serotonin Reuptake Inhibitors Citalopram (Celexa)... 

SSRI, selective serotonin reuptake inhibitor XR, extended-release. Compiled from Ballenger et Ballenger et al/ Bandelow et al/... 

Venlafaxine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It shares these properties with the TCAs amitriptyhne, clomipramine and imip-ramine, but it is the first selective SNRI, with low affinity for muscarinic, histaminic and a-adrenergic receptors. At low doses serotonergic effects predominate, but at higher doses the reuptake of noradrenaline is significantly blocked (Melichar et al. 2001). It is available as immediate and extended release (XR) preparations. 

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