Selective serotonin reuptake inhibitors children

Although tricyclics continue to be used today to treat childhood depression (Zito et ah, 2000), the use in children with ADHD has decreased, most likely because of its association with the sudden deaths of five children (Biederman, 1991). Furthermore, the Physician s Desk Reference (PDR) warns that MPH may inhibit the metabolism of tricyclics, but no such warning exists for DEX or (AMP). Due to the concern that children on this combination of medications are prone to develop more side effects, it is not a recommended form of treatment. Instead, MPH combined with a selective serotonin reuptake inhibitor is preferable for treating a child with ADHD and comorbid depression. 

Garland, E.J. and Baerg, E.A. (2001) Amotivational syndrome associated with selective serotonin reuptake inhibitors in children and adolescents. / Child Adolesc Psychopharmacol 11 181-186. 

Lake, M.B., Birmaher B., Wassick S., Mathos, K., and Yelovich, A.K. (2000) Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence. J Child Adolesc Psychopharmacol 10 35-38. 

Leonard, H.L., March, J., Rickler, K.C., and Allen, A.J. (1997) Review of the pharmacology of the selective serotonin reuptake inhibitors in children and adolescents. J Am Acad Child Adolesc Psychiatry 36 725—736. 

FIGURE 43.1 Pharmacologic treatment algorithm for full syndrome pediatric PTSD. Based on a snythesis of consensus data and clinical reports in the adult and child literature. The author hers no responsibility for the use of this guideline by third parties. SSRI, selective serotonin reuptake inhibitor NEE, nefaza-done SIB, self injurious behavior VLF, venlafaxine VPA, valproic acid. 

FIGURE 47.1 Suggested algorithm for the use of psychotropic medications in the medically ill child or adolescent. CNS, central nervous system GI, gastrointestinal SSRI, selective serotonin reuptake inhibitor TLA, tricyclic antidepressant. 

Ziervogel, C.E (2000) Selective serotonin reuptake inhibitors for children and adolescents. Eur Child Adolesc Psychiatry 9 20-26. 

Reinblatt, S., 8c Riddle, M. (2006). Selective serotonin reuptake inhibitor-induced apathy A pediatric case series. Journal of Child and Adolescent Psychopharmacology, 16,227—233. 

Wilens, T., Biederman, J., Kwon, A., Chase R., Greenberg, L., Mick, E., et al. (2003). A systematic chart review of the nature of psychiatric adverse events in children and adolescents treated with selective serotonin reuptake inhibitors. Journal of Child and Adolescent Psychopharmacology, 13, 143-152. 

Posey DJ, Erickson CA, Stigler KA, McDougle CJ (2006) The use of selective serotonin reuptake inhibitors in autism and related disorders. J Child Adolesc Psychopharmacol 16 181-186. 

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