Selective serotonin reuptake inhibitors buspirone

Landen, M., Eriksson, E., Agren, H. and Fahlen, T. (1999) Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. Journal of Clinical Psychopharmacology, 19, 268-271. 

Anderson DN, Wilkinson AM, Abou-Saleh MT, et al Recovery from depression after electroconvulsive therapy is accompanied by evidence of increased tetra-hydrobiopterin-dependent hydroxylation. Acta Psychiatr Scand 90 10-13, 1994 Anderson IM, Cowen PJ Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology 106 428-432, 1992 Anderson IM, Tomenson BM Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants a meta-analysis. BMJ 310 1433-1438, 1995... 

In addition to buspirone and the non-barbituate, non-BZP hypnotics, selective serotonin reuptake inhibitors (SSRIs), venlafaxine, and other new antidepressants all represent attempts to achieve anxiolytic and hypnotic effects seen with the BZDs, while avoiding their unwanted properties. 

We now have at least three major groups of antidepressants cyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and MAO inhibitors. Additionally, stimulants (such as Dexedrine, Ritalin), atypical antidepressants (bupropion and venlafaxine) and buspirone have been used to treat depression. 

The clearest demonstration of 5-HT, receptor function which can be linked to therapeutic potential has come from the development of drugs which target the 5-HT, and 5-HT,d receptors. The 5-HT,a partial agonists such as buspirone are clinically useful in the treatment of anxiety [39]. In addition, it has been suggested that antagonists of the 5-HT,a receptor, such as pindolol, may lead to a more rapid onset of antidepressant activity when combined with a selective serotonin reuptake inhibitor [40]. Although this particular... 

HTia partial agonists), very different from those of the selective serotonin reuptake inhibitors (SSRIs) and the other antidepressants used to treat anxiety disorders. Buspirone does not cause sedation and has minimal or no potential for abuse or dependence, in contrast to most benzodiazepines. 

Bouwer C, Stein DJ. (1997). Buspirone is an effective augmenting agent of serotonin selective reuptake inhibitors in severe treatment-refractory depression. Souffi Afr Med J. 87(4 suppi) 534-37, 540. 

Buspirone is a partial agonist at 5HT1A receptors St John s wort is a non-selective inhibitor of 5HT reuptake and also upregulates postsynaptic 5HT1A and 5HT2A receptors it therefore causes overstimulation of 5HT1A receptors, leading to the serotonin syndrome. 

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