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Selective PPAR modulators

Netoglitazone is an insulin sensitizer currently in Phase II clinical trials. It is able to modulate both PPAR-a and PPAR-y subtypes of peroxisome proliferator-activated receptor (Phase ll). Metaglidasen (MBX-102) is the (—)-enantiomer of the NSAID halofenate. This selective PPAR-y nuclear receptor agonist is being evaluated (Phase II) as an insulin sensitizer. It is structurally different from the currently marketed glitazones (Figure 8.84). ... [Pg.332]

Westergaard, M. etal. Modulation of keratinocyte gene expression and differentiation by PPAR selective ligands tetradecylthioacetic acid, J. Invest Dermatol., 116, 702, 2001. [Pg.209]

See other pages where Selective PPAR modulators is mentioned: [Pg.103]    [Pg.215]    [Pg.103]    [Pg.215]    [Pg.328]    [Pg.943]    [Pg.1005]    [Pg.75]    [Pg.1856]    [Pg.1372]    [Pg.426]    [Pg.391]    [Pg.190]    [Pg.112]    [Pg.160]    [Pg.109]   
See also in sourсe #XX -- [ Pg.215 ]



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