Selective cross-coupling of secondary organozinc reagents

2 Selective cross-coupling of secondary organozinc reagents 

One of the remaining challenges in the Negishi reaction is the reaction between C 

The relative electron richness of metals bound to NHC ligands when compared with the corresponding phosphine complexes means that oxidative addition will invariably be an easy process. Indeed, even aryl chlorides can undergo oxidative addition well below 0°C. Transmetalation is promoted by an electron-poor metal center, establishing the first major challenge for these electron-rich Pd-NHC catalysts in the catalytic 

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