Select agent, defined

The beneficial effects of ChCMs are many. Nicotine has been reported to enhance cognition, increase attention, reduce anxiety, decrease nociceptive perceptions, and act as a neuroprotectant.37 However, the liabilities associated are significant as nicotine causes decreased body temperature, reduction of locomotor activity, and induction of seizures.37 Nicotine also possesses a drug discrimination or cue upon administration.37 These benefits and liabilities show the diversity of nAChRs and the potential for defining each pharmacological effect with selective agents. 

Figure 26 Polymers generated by ROMP can function as antimicrobial agents. The minimal inhibitory concentration that prevents 90% bacterial growth (MIC90) and hemolytic activity toward red blood cells (HC5o = concentration that promotes lysis of 50% of red blood cells) were assessed for each compound. Selectivity is defined by the ratio of HC50/MIC90.3k and 10k refer to polymers with molecular weights of SOOOand lOOOOg mol" respectively.

The first and best-studied allosteric site on GPCRs is that on the muscarinic receptor [9,10,12,19,20]. For the five subtypes of these receptors that have been cloned and pharmacologically defined as Mi to M5, various agents have been identified that allosterically regulate selectively these... 

Nausea and vomiting that occur within 24 hours of chemotherapy administration is defined as acute, whereas when it starts more than 24 hours after chemotherapy administration, it is defined as delayed. The emetogenic potential of the chemotherapeutic agent or regimen (see Table 27-2) is the primary factor to consider when selecting an antiemetic for prophylaxis of CINV. 

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