Seizures kainic acid -induced epilepsy

Paczynski RP, Meyer FB, Anderson RE Effects of the dihydropyridine Ca " channel antagonist nimodipine on kainic acid-induced limbic seizures. Epilepsy Res 6 33-38, 1990... 

Both peri-ictal and post-ictal changes in DU occur in animal models and in human epilepsy after SE and brief seizures. In the peri-ictal phase, reduced diffusivity is seen in animal models and in up to 50% of patients after seizures in one series (Diehl et al., 2005). This may be secondary to cellular swelling and reduced extracellular space due to the failure of ATPase which results in the accumulation of intracellular sodium and water (Wang et al., 1996). Transient decreases in diffusivity are seen post-ictally in kainic acid-induced SE in rodents. Increase in diffusivity is seen with chronic pilocarpine-induced seizures thought to be due to the loss of cellular and structural integrity. 

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