Seizure disorders clorazepate

Although diazepam is an effective agent for treatment of status epilepticus, its short duration of action is a disadvantage, leading to the more frequent use of lorazepam. Although diazepam is not useful as an oral agent for the treatment of seizure disorders, clorazepate is effective in combination with certain other drugs in the treatment of partial seizures. The maximal initial dose of clorazepate is 22.6 mg per day in three portions for adults and 15 mg per day in two doses in children. Clorazepate is not recommended for children under the age of 9. 

Librium, others) Clorazepate preanesthetic medication Anxiety seizure disorders 2 (prodrug) active metabolite Oxazepam glucuronide... 

Clorazepate Demoxepam Anxiety disorders, seizure disorders... 

Clorazepate (tranxene, others) Oral Anxiety disorders,seizure disorders Prodrug nordazepam formed by decarboxylation in GI tract 2.0 0.9 3.75-20, bid-qid ... 

Anticonvulsant As adjunctive therapy in the management of partial seizures (clorazepate) adjunctively in status epilepticus and severe recurrent convulsive seizures (diazepam IV) adjunctively in convulsive disorders (diazepam oral). Preoperative For preoperative apprehension and anxiety (chlordiazepoxide, diazepam IV) prior to cardioversion for the relief of anxiety and tension and to diminish patient s recall (diazepam IV) adjunctively prior to endoscopic procedures for apprehension, anxiety, or acute stress reactions and to diminish patient s recall (diazepam) ... 

Clorazepate is a benzodiazepine that potentiates action of GABA, an inhibitory neurotransmitter, resulting in increased neuronal inhibition and CNS depression, especially in limbic system and reticnlar formation. Clorazepate is indicated in the management of anxiety disorders relief of acnte alcohol withdrawal symptoms and adjunctive therapy in management of partial seizures. 

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