Seeding Strategy

The influence of seeding on crystallization is often critical to control of a process, and the importance of an appropriate seeding strategy cannot be overemphasized. While some systems will and do nucleate spontaneously, control of a process, especially on scale-up, that depends on spontaneous nucleation can be subject to extreme process variation for several reasons, including... 

Of these critical factors, the one that is most subject to predetermination and control is the seed added at the outset. The following section offers guidelines on effective seeding strategy and methods. 

Various cooling temperature and seeding strategies were applied to select the best one for cooling batch crystallisation. Crystals produced were filtered, dried and the size range analysed using the Malvern Mastersizer X. 

Essential factors to limit or prevent oiling-out are controlled supersaturation and efficient seeding strategies. 

In the case of co-crystallization, a seeding strategy has two main goals (i) to ensure the presence of the co-crystal phase in solution as soon as the crystalline growth starts, (ii) to avoid uncontrolled primary nucleation of another solid phase previous to the presence of the co-crystal seeds. 

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