Sedoheptulose diphosphate, from glucose

The ultimate derivation from glucose, shown in diagram 1, is considered in the section on isotopic evidence. A combination of mutant, enzymic, and isotopic techniques suggests that sedoheptulose-1,7-diphosphate is an intermediate in the conversion (456a,b, 823a). 

Fia. 14. Distribution of carbon atoms from glucose (C-1, C-2) into sedoheptulose diphosphate and shikimic acid. 

Sedoheptulose 1,7-diphosphate has been prepared by enzymic condensation of D-erythrose 4-phosphate with dihydroxyacetone phosphate . Mannoheptulose phosphate was isolated from avocado leaves . 3-Keto-D-araboheptose phosphate was obtained by incubation of glucose... 

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