Sedatives 1,3-thiazines

The antiemetics and antivertigo drug may have additive effects when used with alcohol and other CNS depressants such as sedatives, hypnotics, antianxiety drugp, opiates, and antidepressants. There may be additive anticholinergic effects (see Chap. 25) when administered with drag s that have anticholinergic activity such as the antihistamines, antidepressants, pheno-thiazines, and disopyramide The antacids decrease absorption of the antiemetics. 

As mentioned in CHEC(1984), phenothiazine derivatives are best known as pharmaceuticals for the central nervous system, and are used not only for treatment of various mental illnesses <1986AXC1083> but also as neuroleptics, sedatives, analgesics, anti-emetics, and antihistamines <1987AXC1737>. A review has appeared on use of pheno-thiazines in the treatment of Creutzfeldt-Jacob disease <2001JAA411>. 

Cardiac glycosides Digitalis-like effects thiazines, sedatives, alcohol Potentiation of digitalis... 

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