Securiflustra securifrons Securamines

Rahbsek L. Carsten, C. (1997) Three new alkaloids, securamines E-G, from the marine biyozoan Securiflustra securifrons. J. Nat. Prod., 60, 175-7. 

Rahbaek L, Anthoni U, Christophersen C, Nielsen PH, Petersen BO (1996) Marine Alkaloids. 18. Securamines and Securines, Halogenated Indole-Imidazole Alkaloids from the Marine Bryozoan Securiflustra securifrons. J Org Chem 61 887... 

Rahbaek, L., Anthoni, U., Christophersen, C., Nielsen, P. H., and Petersen, B. O., Marine alkaloids. 18. Securamines and securines, halogenatd indole-imidazole alkaloids from the marine bryozoan Securiflustra securifrons, J. Org. Chem., 61, 887, 1996. 

Securamine C from the marine bryozoan Securiflustra Securifrons family has recently been isolated and characterized by researchers at the University of Copenhagen. This interesting hexacyclic structure is an indole-imidazole alkaloid from a family of alkaloids that has yielded important biological activity. This proposal outllines a total synthesis of 1. 

The securines, securamines, chartellines, and chartellamides are members of a structurally unique class of natural products isolated from the bryozoa Chartella papyracea and Securiflustra securifrons by Christophersen and coworkers [65-69] (Fig. 7). Chartellines represent a small family of marine-derived, architecturally unique alkaloids that include chartelline A, chartelline B, and chartelline C, which only differ in the number and position of bromines. Chartelline C (173) is composed of indolenine, imidazole, and jS-lactam heterocycles arrayed in a dense, Ji-stacking framework that poses an obvious challenge for its synthesis [70, 71], Though numerous efforts have been made towards chartelline C (173), rally Baran and coworkers have reported its synthesis [70, 71]. 

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