Secondary haemostasis

Plasma phase (secondary haemostasis - clotting). In which blood clots develop within a minute or two. Traumatised vessels and platelets liberate activating factors, which initiate the clotting process. 

Pathophysiologically, primary haemostatic defects, characteristically due to malfunction of vascular endothelial or platelets, are exemplified by von Willebrand disease and agents such as aspirin and non-steriodal anti-inflammatory drugs (NSAID) where there is a prolonged bleeding time or abnormality in closure using the laboratory equivalent of platelet function analyse the PEA-100. In contrast, secondary bleeding, follows a period of haemostasis... 

Deposition and adhesion of cells on surfaces play an important part in many biological processes. For example, blood cell deposition and adhesion on surfaces are essential in the vital process of haemostasis and fundamental in the events leading to thrombus formation. Also, malignant cell adhesion on various tissues is responsible for the growth of secondary tumors, after being carried in the blood stream from the primary tumor location. 

Menard M, Meyers KM, Prieur DJ. Primary and secondary lysosomes in megakaryocytes and platelets of cattle with the Chediak-Higashi syndrome. Throm Haemostasis 1990 64 156-160... 

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