Screening Fit Values and Enrichment Factors

Class Number of Virtual Hits Number of Identified a1A Antagonists Hit Rate (%) Yield (%) 

Class Number of a1A Antagonists Among Top 5% of Database Hit Rate (%) Yieldb (%) Enrichment Factor 

All compounds have been scored based on their fit value onto the respective pharmacophore [16]. Hit rate = (number of true actives in hit list)/(number of compounds in hit list) x 100. 

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