Scrapie polyanions

The development of effective treatments for TSE diseases remains problematic. A number of compounds have been identified that can prolong the lives of scrapie-infected rodents if administered before or near the time of infection. These compounds include various polyanions (e.g., pentosan polysulfate (Kimberlin and Walker, 1986 Lado-... 

Caughey, B., and Raymond, G.J. (1993b). Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells./. Virol. 67, 643-650. 

Kimberlin, R.H., and Walker, C.A. (1986). Suppression of scrapie infection in mice by hetero- polyanion 23, dextran sulfate, and some other polyanions. Antimicrob. Agents Chemother. 30, 409-413. 

Ladogana, A., Casaccia, P, and Ingrosso, L. (1992). Sulphate polyanions prolong the incubation period of scrapie-infected hamsters./. Gen. Virol. 7S, 661-665. 

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