Scorzonera humilis

A new class of secondary metabolites tyrolobibenzyls A 36 and B 37 were isolated from Scorzonera humilis (Asteraceae) of Tyrolean origin. Compounds 36 and 37 were shown to possess a unique phenylethylbenzofuran skeleton <00HCA292O>. The structure of the dimeric coumarin 38 was confirmed by an X-ray diffraction study, as well as by a photochemical synthesis from its co-occurring monomer bergapten <00H(53)441>. 

Six bibenzyl glycosides, tyrolobibenzyls A-F, were isolated from Scorzonera humilis (Asteraceae) of tyrolean origin [82-84]. Tyrolobibenzyls C and E (147, 148) are simple bibenzyl glucosides with an acetyl group at C-1, while tyrolobibenzyls A, B, D and F (191-194) possess a unique phenylethyl-benzofuran backbone and represent a new class of natural compounds attributed to group C. 

Nowadays, LC-MS systems have been often applied to identify and quantify stilbenoids, for example, bibenzyls in Scorzonera humilis [84], phenanthrenes of Dendrobium chrysanthum [201], resveratrol oxidative products [257] and stilbenes derivatives [363]. 

B 120, D 121, and F 122 from Scorzonera humilis L. (Asteraceae) are the typical constituents of this group [70-72]. 

Zidom C, EHmerer-Miiller EP, Stuppner H (2000) Tyrolobibenzyls - novel secondary metabolites from Scorzonera humilis. Helv Chim Acta 83 2920-2925... 

Zidom C, Ellmerer-MiiUer EP, Sturm S, Stuppner H (2003) Tyrolobibenzyls E and F from Scorzonera humilis and distribution of caffeic acid derivatives, lignans and tyrolobibenzyls in European taxa of the subtribe Scorzonerinae (Lactuceae, Asteraceae). Phytochemistry 63 61-67... 

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