Scintigraphic analysis

Goates JJ, Morton KA, Whooten WW, Greenberg HE, Datz EL, Handy JE, Scuderi AJ, Haakenstad AO, and RE Lynch (1990). Comparison of methods for calculating glomerular filtration rate technetium-99m-DTPA scintigraphic analysis, protein-free and whole-plasma clearance of technetium-99m-DTPA and iodine-125-iothalamate clearance. Journal of Nuclear Medicine 31 424-429. 

Bolus Injection. The bolus mode consists of the successive perfusions of as many bolus (n) volumes as necessary to reach the cumulative activity required by the scintigraphic examination. A mathematical analysis of this technique results in the following equation ... 

The pharmacokinetics of XYZ1234 formulations after release in different regions of the gastrointestinal tract reveal similar exposure for the proximal small bowel as compared to the immediate release formulation, halved exposure for the distal small bowel and only poor absorption from the ascending colon. Thus colonic resorption cannot be relied on for the development of an extended release formulation. Analysis of the scintigraphic data has confirmed release of the formulation at the target locations in the required number of subjects. 

Several antigens have been proposed as putative markers of angiogenesis, but only a few have been extensively characterized by immunohistochemistry, by in vivo biodistribution analysis and by scintigraphic procedures in patients with cancer or other diseases. 

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