Schmidt protocol

In addition to possible variations between methods, there may also be variations in Tg within a method, depending on the measurement protocol employed. For example, the DCS Tg midpoint for a quench-cooled ( 100 K/min) maltose sample, heated at a scanning rate of lOK/min, was 43.1 0.21 °C, whereas for a maltose sample prepared using equal heating and cooling rates of lOK/min the Tg was 41.2 0.10°C (Schmidt and Lammert, 1996). For the same samples, DSC Tg Active temperatures were also calculated. Tg Active for the quench-cooled sample was 41.0 0.20 °C, whereas for the equal-rate sample, Tg Active was 38.6 0.06 °C. 

The Schmidt reaction of cyclic ketones with hydrazoic acid affords convenient access to ring-expanded N-unsub-stituted lactams but extension of this process to alkyl azides to provide Aralkyl lactams is capricious in nature. A protocol... 

G. Giibitz, M.G. Schmidt (Eds.), Chiral separations Methods and protocol, Totowa, NJ Humana Press (2004). 

Schmidt, T. A., Atcheson, R., Rederiuk, C., Mann, N. C., Finney, T., Ruiier, D., et ai. (2001). Hospital follow-up of patients categorized as not needing an ambulance using a set of emergency medical technician protocols. Prehospital Emergency Care, 5, 366-370. 

An example of intramolecular aminomercuration has been reported by Weimeb as part of the synthetic strategy to the tricyclic nucleus of madangamine A - an alkaloid that shows cytotoxicity toward a number of tumor cell lines (equation 15). Pearson has recently reported the first example of an azidomercuration involving aliphatic azides (see equation 16) according to a protocol that exhibits wider applicability and is, therefore, more convenient than the analogous acid-promoted Schmidt reaction. ... 

Another fascinating intramolecular process involves the spirocyclic epoxide 103, which carries a pendant azide group. Under the influence of ethylaluminum chloride, this substrate undergoes Lewis acid assisted cyclization followed by an intramolecular Schmidt reaction and subsequent in situ reduction of the intermediate iminium species 105 upon addition of sodium borohydride. This protocol was used as a key step in a novel synthesis of indolizidine alkaloids of pharmaceutical interest <03OL583>. 

Both assembly of the methyl glycoside 66 (see Scheme 29) and coupling of the appropriately protected trichloroacetimidate derivative 96 with the calicheami-cinone y precursor97 [222] (Scheme 37) using Schmidt s protocol [170c] were... 

Schmidt 1989 40 depressive syndromes (various aetiologies, HAMD >16) [ICD] Psychotonin M 3 x 30 drops 4 weeks A 28 patients per protocol (16 Hyp/12 Pic) R HAMD decrease in mean total score from 29.25 to 9.75 (placebo 29.5 to 19.5), p<0.001 (U-test) responder rate (decrease in total score >50% or total score <10) 63% (placebo 33%) STAI XI and X2 no significant inter-group differences Self-rating scale for psychophysical condition decrease in symptom severity significantly greater in active treatment group compared with placebo, p<0.05 (Chi-square test)... 

Hauer, Schmidt and Kuhn 1991 120 mild depression (HAMD 16-20) [ICD-9 304.4, 309.9] Psychotonin M 3 x 30 drops 6 weeks A 116 patients, i-e. randomized patients except 4 with HAMD <16 94 per protocol patients (Hyp 53, Pic 41) no statistical testing R HAMD decrease in mean total score from 21.6 to 8.9 (placebo 20.9 to 16.1) responder rates (decrease in total score 550% or total score 510) 65.9% (placebo 25%) Selfrating scale D-S decrease in mean total score from 11.7 to 4.9 (placebo 12.7 to 8.1) HAMA decrease in mean total score from 11.9 to 4.5 (placebo 12.1 to 8.2) Patients global judgement 51.7% "very much improved" (placebo 19.6%)... 

Chlamydocine, a cyclotetrapeptide belonging beside WF3161 to the most potent cancerostatics in vitro. By using the Boc/OPfp protocol, both 4-peptides can be synthesized in high yields. The nonnatural amino acid (S)-2-amino-8-oxo-(S)-9,10-epoxidecanoic acid (AOE) present as a building block in both cyclopeptides was assembled stereoselectively in a seven-step synthesis [U. Schmidt et al.. Tetrahedron Lett. 1988, 29, 3057]. 

Schmidt P, Berger C, Scheidt HA, Bemdt S, Bunge A, Beck-Sickinger AG, Huster D (2010) A reconstitution protocol for the in vitro folded human G protein-coupled Y-2 receptor into lipid environment. Biophys Chem 150 29-36... 

---