Schizothrix calcicola

Lyngbya majuscula/Schizothrix calcicola (dolastatin 12, 15-epi-dolastatin 12, lyngbystatiii 1, 15-epi-lyngbystatin 1) [134]. A Gastropoda Dolabdla auricularia (dolastatins 11-12) [120]. 

Dolastatins 11, 12 79, 81, first isolated from the sea hare Dolahdla auricularia and now clearly considered to be of dietary cyanobacterial origin, can be mentioned as examples [133]. The structurally closely related cyclodepsipeptide majuscula-mide C 80 has been isolated from defined cyanobacterial sources [119]. This was one and a half decades before dolastatin 12 81 was furthermore detected in extracts from a marine cyanobacteria assemblage (Lyngbya majuscula/ Schizothrix calcicola)... 

Our interest in the dolastatins was stimulated by our recent isolation of a C-15 epimeric mixture of an N-methylated analog of dolastatin 11 (3), which we termed lyngbyastatin 1 (4a) and epilyngbyastatin 1 (4b), and dolastatin 12 (5a) (also as a C-15 epimeric mixture) from a L. majuscula/Schizothrix calcicola assemblage collected near Guam. Dolastatins 11 (3) and 12 (5a) were originally isolated as potent cytotoxic compounds from D. auricularia. ... 

The polysaccharide moiety of the lipopolysaccharide of Schizothrix calcicola contains 2-amino-2-deoxy-D-glucose, D-galactose, D-glucose, D-mannose, D-xylose, and L-rhamnose. In contrast to many enterobacterial lipopoly-saccharides, the major fatty acid component has been identified as 3-hydroxy-palmitic acid and not 3-hydroxymyristic acid. 

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