Schizophrenia types

Another hypothesis (Crow, 1982) involves a division of schizophrenias into two types Type I corresponds to acute schizophrenia or schizophreniform disorder in which one observes more positive symptoms of hallucinations and delusions with a good prognosis and excellent response to neuroleptics... Type II represents chronic schizophrenia with affective flattening, poverty of speech and loss of drive, the so-called negative symptoms of schizophrenia. Type II patients respond less well to neuroleptics... (Snyder, 1982). Type I patients would fit into the dopamine hypothesis whereas a pathophysiological basis other than dopaminergic hyperactivity must be assumed for type II patients. However, as pointed out by Snyder (1982). "one should be cautious about drawing such a distinction. ... 

After the publication of the Strauss et al. article, there was considerable interest in whether a subtype of schizophrenia could be defined by positive or negative symptoms. Crow (1980) postulated the existence of two distinct syndromes within schizophrenia, Type I and Type II. Type I was characterized as having more positive symptoms, more acute, responding well to neuroleptics, and with limited intellectual impairment. Type II was defined by irreversible flat affect, insidious onset and chronic course, responding poorly to neuroleptics, and more often associated with gross brain abnormalities. Later, Crow clarified the two types could coexist within the same individual, thus bringing his ideas more in line with the domain concepts of positive and negative symptoms (Crow, 1985). 

Trial validity is also grossly affected by the type of trial carried out. In schizophrenia there are several health-care decision models, retrospective mirror-image analyses (with or... 

The anxiety disorders are common and surprisingly disabling conditions. Studies on the health economics of generalized anxiety disorder, panic disorder, social anxiety disorders and obsessive compulsive disorder document the cost to the individual and to society. Attention has focused on the major psychiatric disorders such as depression, schizophrenia and the dementias. Studies suggest that many anxiety disorders are of early onset and too often chronic they are quite common and impose a heavy burden on society. More studies will be needed to discern the fine grain in the survey material and to identify more precisely the location and type of societal costs. These factors will vary from country to country, from district to district, between men and women and between various age groups. 

Schizophrenia A mental disorder characterized by a spedal type of disintegration of the personality. [NIH]... 

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