Schizophrenia neurodegenerative model

Lesion models are based on the idea that schizophrenia is, in part, a neurodegenerative or neurodevelopmental disorder. These lesions are generally neurotoxic, and have variable response to antipsychotic drugs (Marcotte et al., 2001). Recently, a novel model was studied in which pregnant mouse... 

Fiskum G, Murphy AN, Beal MF (1999) Mitochondria in neurodegeneration acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Row Metab 19 351-369 Gallagher S (2004) Neurocognitive models of schizophrenia a neurophenomenological critique. Psychopathology 37 8-19... 

In addition, an increase in the enzymatic activity of PI-PLC, PC-PLD, and PLAj have been detected in a variety of neurological disease states including Alzheimer s disease, Huntington s disease, schizophrenia, and in some neurodegenerative disease models. Although the key neurochemical mechanisms underlying these enzymatic abnormalities are still unknown, it is likely that DAG levels will be abnormal as a result. 

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