Schizophrenia mesoridazine

Whatever the underlying causes may be, neuroleptic medications are the most effective treatment for schizophrenia. All antipsychotic medications have some form of dopamine receptor antagonism and they are distinguished by their chemical class. The phenothiazines include chlorpromazine (Thorazine), thioridazine (Mellaril), mesoridazine (Serentil), trifluoperazine (Stelazine), fluphenazine (Prolixin), and prochlorperazine (Compazine). The thioxanthenes include chlorprohixine (Taractan) and thiothixene (Navane). Butyrophenones are represented by haloperidol (Haldol). Loxapine (Loxitane) is a dibenzoxapine, and molindone (Moban) is a dihydroindolone. 

Mesoridazine acts analogous to other phenothiazine neuroleptics and is used for schizophrenia, behavioral problems, psychoneurotic displays, and in severe and chronic alcoholism. Synonyms of this drug are lidanil, serentil, and others. 

Mesoridazine has not been systematically studied in treatment-refractory schizophrenia... 

Gardos G, Tecce JJ, Hartmann E, Bowers P, Cole JO. Treatment with mesoridazine and thioridazine in chronic schizophrenia II. 

Mesoridazine has been used effectively in schizophrenia, behavioral problems in mental deficiency and chronic brain syndrome, alcoholism, and psychoneurotic manifestations associated with neurotic components of personality disorders. 

The besylate salt of mesoridazine 43 is a commercially available antipsychotic medication that is used for treating schizophrenia and mania as well as major depression, anxiety, or severe behavior disorders in children. Mesoridazine 43 has four enantiomers, but the commercial samples are sold as only one diastereomeric pair. The methyl sulfoxide peak of 43 in the H NMR spectrum in the presence of 39 exhibits a peak for each of the four enantiomers. The areas of the sulfoxide resonances were used to compare the diastereomeric ratio of freshly prepared samples of 43 with commercial samples for changes in the ratio of the different isomers. ... 

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