Schizophrenia clinical phenotype

Some studies have reported associations of serotonin receptor variants with clinical phenotypes. Cys23Ser and Gly22Ser 5-HTiA receptor variants, for example, have been associated with phenotypes such as intractable suicidal ideation [98], ADHD [100], bipolar disorder, and schizophrenia [98, 99, 109-116] and the -1348 A/G polymorphism of the 5-HT receptor has been associated with schizophrenia, eating disorders, and psychotic symptoms in Alzheimer s patients [94, 100, 117, 118], although these associations are not consistent across different studies. 

---