Schemes properly drawn

Here is a properly drawn reaction scheme. The arrow and the one-line structure are centered from top to bottom in the height of the long structure the reaction arrow and the plus sign have an equal amount of space on both sides and the full column width is used. 

As shown in Fig. 16.6, we planned to use a pre-registered combinatorial chemistry protocol (LJ0194) to synthesize the targeted library. PGVL Hub allowed us to easily search and load this pre-registered reaction scheme into a design session without the need to draw a reaction scheme required for product enumeration (see Fig. 16.7). Even for this simple reaction, a simple reaction scheme drawn by users may not be sufficient to ensure proper formation of product structures in the case where bonds associated with chiral centers are near the reactive sites on the reactants. 

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