Scale extrusion, spheronization

Newton JM, Chapman SR, Rowe RC. The assessment of the scale-up performance of the extrusion/spheronization process. Int J Pharm 1995 120 95-99. Kristensen HG. In Lindberg NO, ed. Industrial Wet Granulation. Acta Phar-maceutica Suecica. 1988 25(4-5) 187-204. 

Consideration should be given to the availability of small-scale equipment, which is vital for development work prior to scale-up on pilot- or production-scale machines. Equipment choice is not necessarily based on maximum throughput rate, since the subsequent processing stages (e.g., cutting, spheronization, and drying) are batch processes and are therefore, a rate-limiting factor in production. Since extrusion is a continuous process, it allows adequate production rates for most purposes with any of the above mentioned extruder types. 

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