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Scaffolds for controlled DNA delivery

Controlled delivery of viral or non-viral DNA (lipoplexes or naked DNA) is an important aspect of gene therapy. The potential of nanofiber scaffolds for site-specific delivery of genetic material is beginning to be appreciated. Luu et al. (2003) recently demonstrated for the first time successful incorporation of plasmid DNA into an electrospun nanofiber scaffold. Polymers, PLGA (LA GA 75 25), and a poly(D,L-lactide)-poly(ethylene glycol) (PLA-PEG-PLA) block copolymer were electrospun from 10-15% solutions in DMF, and the DNA used was pCMV 3 plasmid. The pCMV P plasmid with... [Pg.193]

Nie H, Wang CH (2007) Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA. J Control Release 120 111-121... [Pg.429]


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See also in sourсe #XX -- [ Pg.157 , Pg.158 , Pg.159 , Pg.160 , Pg.161 ]

See also in sourсe #XX -- [ Pg.157 , Pg.158 , Pg.159 , Pg.160 , Pg.161 ]




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Controlled DNA Delivery

Controlled delivery

DNA delivery

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