Saytsev s rule

Traditionally, these two opposite preferences—for the more or the less substituted alkenes—have been called Saytsev s rule and Hofmann s rule, respectively. You will see these names used (along with a number of alternative spellings—acceptable for Saytsev, whose... 

The Saytzeff rule (or Zaitsev s rule or Saytsev s rule named after Alexander Mikhailovich Zaitsev) implies that base (sterically unhindered) induced eliminations will lead predominantly to the alkene in which the double bond is more highly substituted. However, if the base, for example, is potassium f-butoxide [(CH3)3COK], the bulkiness prohibits the base from pulling the proton off of the most substituted carbon. In such cases, the less substituted alkene, i.e. Hofmann elimination, is preferred. 

Traditionally, these two opposite preferences—for the more or the less substituted alkenes—have been called Saytsev s rule and Hofmann s rule, respectively. You will see these names used (along with a number of alternative spellings— acceptable for Saytsev, whose name is transliterated from Russian, but not for Hofmann this Hofmann had one f and two n s), but there is little point remembering which is which (or how to spell them)—it is far more important to understand the reasons that favour formation of each of the two alkenes. 

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